External Validation of the Phoenix Sepsis Score in Children With Suspected Community-Acquired Sepsis

E Long; ML Borland; S George; S Jani; E Tan; N Phillips; A Kochar; S Craig; A Lithgow; A Rao; S Dalziel; E Oakley; S Hearps; B Gelbart; S Mcnab; F Balamuth; SL Weiss; N Kuppermann; C Brad; A Williams; FE Babl; CL Wilson

Journal article

External Validation of the Phoenix Sepsis Score in Children With Suspected Community-Acquired Sepsis

E Long, ML Borland, S George, S Jani, E Tan, N Phillips, A Kochar, S Craig, A Lithgow, A Rao, S Dalziel, E Oakley, S Hearps, B Gelbart, S Mcnab, F Balamuth, SL Weiss, N Kuppermann, C Brad, A Williams Show all

JAMA Network Open | JAMA Network | Published : 2025

DOI: 10.1001/jamanetworkopen.2025.1412

Abstract

Importance: The novel Phoenix Sepsis Score and sepsis criteria were derived and validated using a multicountry dataset and proposed as a new definition for sepsis in children. Objective: To externally validate the Phoenix Sepsis Score and sepsis criteria in a cohort of children hospitalized with suspected community-acquired sepsis. Design, Setting, and Participants: This diagnostic study used data from the multicenter, multicountry Sepsis Epidemiology in Australian and New Zealand Emergency Departments (SENTINEL) study, collected from 2021 to 2023 and including 90-day follow-up. Children admitted to the hospital through 11 emergency departments in Australia and New Zealand and treated with p..

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